Neglected Tropical Diseases


Neglected tropical diseases (NTDs) are a diverse group of tropical infections which are especially common in low-income populations in developing regions of Africa, Asia, and the Americas.


149
Countries
1,400,000,000
At risk
216,000,000
Cases
142,000
Deaths
Data: World Health Organization (WHO), 2017

Background Information


NTDs are a group of tropical infections which are especially endemic in low-income populations in developing regions of Africa, Asia, and the Americas. Different organizations define the set of diseases differently. In sub-Saharan Africa, the impact of these diseases as a group is comparable to malaria and tuberculosis. Some of these diseases have known preventive measures or acute medical treatments which are available in the developed world but which are not universally available in poorer areas. In some cases, the treatments are relatively inexpensive. For example, the treatment for schistosomiasis is US$0.20 per child per year. Nevertheless, control of neglected diseases is estimated to require funding of between US$2 billion to US$3 billion over the next five to seven years.

These diseases are contrasted with the big three diseases (HIV/AIDS, tuberculosis, and malaria), which generally receive greater treatment and research funding. The neglected diseases can also make HIV/AIDS and tuberculosis more deadly. However, some pharmaceutical companies have committed to donating all the drug therapies required and mass drug administration has been successfully accomplished in several countries. Neglected tropical diseases include, in order of decreasing prevalence:

Soil transmitted helminths, including:

  • roundworms such as Ascaris lumbricoides which causes ascariasis;
  • whipworm which causes trichuriasis;
  • hookworms which, depending on the species, cause necatoriasis and ancylostomiasis.

Neglected Diseases:
  • Snail fever (schistosomiasis)
  • Elephantiasis (Lymphatic filariasis)
  • Trachoma
  • River blindness (onchocerciasis)
  • Kala-azar black fever (and other clinical forms of leishmaniasis)
  • Chagas disease (American trypanosomiasis)
  • Leprosy
  • African sleeping sickness (Human African Trypanosomiasis)
  • Guinea-worm (dracunculiasis)
  • Buruli ulcer

NTD diagnosis using the Em1


Capable of diagnosis Yes (100x, 400x, 600x, 1000x)
Trialed/validated Yes (Ivory Coast)

Schistozome worm egg identification using the Em1


Testimonial


I have used several Em1s for schistosomiasis and soil-transmitted helminth diagnosis and they perform exceptionally well with very high sensitivity and specificity. In my opinion, this instrument is the only portable compact microscope in the world capable of serious medical use in remote and arduous settings


Isaac I. Bogoch, MD
DIVISIONS OF INTERNAL MEDICINE AND INFECTIOUS DISEASES, TORONTO GENERAL HOSPITAL, CANADA








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